The research goals of the Exercise Physiology and Biochemistry Laboratory are to determine:
1) important changes in physiological function with aging;
2) modulation of those changes by biological factors (e.g., adiposity, vitamin D) and lifestyle behaviors (e.g., physical activity and fitness);
3) the efficacy of exercise interventions for reversing adverse changes in physiological function and cognitive declines with aging; and
4) the integrative (systemic to molecular) biological mechanisms that mediate physiological and cognitive changes with aging and the effects of modulating influences and interventions on those changes.
We employ a wide range of contemporary experimental techniques to study these issues in human subjects and rodents in cross-sectional, intervention, and longitudinal study designs. Emphasis is placed on the integrative nature of the physiological and pathophysiological processes involved from a mechanistic perspective.
The laboratory is supported by research grants from the National Research Foundation (NRF) of Korea.
· The effect of voluntary physical activity on ADHD pathology and its clinical symptoms (2014R1A1A2056473).
· Unraveling the cellular mechanisms leading to the effects of exercise training intervened at different stages of Alzheimer’s disease (2013S1A2A2034953).
· Effects of exercise training on pathological states of Alzheimer’s disease in 3xTg-AD mice (2012R1A1A2006180).
· Effect of exercise training on non-alcoholic fatty liver disease in high-fat diet-induced obese mice (32A-2011-1-G00049).